Two Preadipocyte Subtypes Cloned from Human Omental Fat
نویسندگان
چکیده
منابع مشابه
Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots.
Fat depots vary in function and size. The preadipocytes that fat cells develop from exhibit distinct regional characteristics that persist in culture. Human abdominal subcutaneous cultured preadipocytes undergo more extensive lipid accumulation, higher adipogenic transcription factor expression, and less TNF-alpha-induced apoptosis than omental preadipocytes. We found higher replicative potenti...
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Reuptake plays an important role in regulating synaptic and extracellular concentrations of glutamate. Three glutamate transporters expressed in human motor cortex, termed EAAT1, EAAT2, and EAAT3 (for excitatory amino acid transporter), have been characterized by their molecular cloning and functional expression. Each EAAT subtype mRNA was found in all human brain regions analyzed. The most pro...
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39 40 Context The polycystic ovary syndrome (PCOS) is frequently associated with visceral obesity, suggesting 41 that omental adipose tissue might play an important role in the pathogenesis of the syndrome. 42 Objective To the study of the expression profiles of omental fat biopsies obtained from morbidly obese 43 women with or without PCOS at the time of bariatric surgery. 44 Design Case-contr...
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Fat depots vary in size, function, and potential contribution to disease. Since fat tissue turns over throughout life, preadipocyte characteristics could contribute to this regional variation. To address whether preadipocytes from different depots are distinct, we produced preadipocyte strains from single abdominal subcutaneous, mesenteric, and omental human preadipocytes by stably expressing h...
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ژورنال
عنوان ژورنال: Obesity Research
سال: 1993
ISSN: 1071-7323
DOI: 10.1002/j.1550-8528.1993.tb00596.x